The purpose of this research was to prepare and evaluate the pantoprazole sodium enteric coated tablets using eudragit L30D55 as aqueous enteric polymer by dip coating technique and to optimize the critical process variables involved. Core tablets were prepared by wet granulation technique; prepared tablets were evaluated for physicochemical parameters and the results obtained are within acceptable limits. Results of preliminary trials indicate that inlet air temperature, dipping time and pan speed influences the efficiency of the coating process, critical coating parameters like inlet air temperature, dipping time and pan speed were optimized. Enteric coated tablets were evaluated for all physicochemical parameters and in-vitro drug release studies. The optimized batch showed better results when the dip time of 2 sec, inlet air temperature at 60 to 70°C and pan speed of 10 to 25 rpm were maintained.
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